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Enough is enough, I've had it with these snakes! is a quote from the Snakes on a Plane trailer, by the star of the movie, Samuel L. Jackson. The meme experienced a short boom of popularity when the trailer was first released, possibly more so than the V meme's overnight success, though it's become a meme of the past due to its limited uses.

The meme enjoyed many iterations at the time, through replacing the word "snakes" to give new meaning to the quote, such as "Enough is enough, I've had it with all these rakes", and the ability to shop the movie's poster to have Samuel L. Jackson have enough of whatever the Anon can think of (Enough is enough, I've had it with these DESUS).